A Multilayer Grow-or-Go Model for GBM: Understanding the Effects of Anti-Angiogenic Drugs

SPEAKER: Dr. H. Fathallah, University of Alabama, Birmingham

TITLE: A Multilayer Grow-or-Go Model for GBM: Understanding the Effects of Anti-Angiogenic Drugs

ABSTRACT: The recent use of anti-angiogenesis (AA) drugs for the treatment of glioblastoma multiforme (GBM) has uncovered unusual tumor responses. I will discuss a new mathematical model that takes into account the ability of proliferative cells to become invasive under hypoxic conditions. We show that the model simulations generate the multilayer structure of GBM, namely proliferation, brain invasion, and necrosis. The model is validated and interrogated to derive fundamental insights in cancer biology and on the clinical and biological effects of AA drugs.

HOSTS: Professors O. Karakashian and S. Wise

Refreshments will be available at 3:15 p.m.