SPEAKER: Dr. H. Fathallah, University of Alabama, Birmingham
TITLE: A Multilayer Grow-or-Go Model for GBM: Understanding the Effects of Anti-Angiogenic Drugs
ABSTRACT: The recent use of anti-angiogenesis (AA) drugs for the treatment of glioblastoma multiforme (GBM) has uncovered unusual tumor responses. I will discuss a new mathematical model that takes into account the ability of proliferative cells to become invasive under hypoxic conditions. We show that the model simulations generate the multilayer structure of GBM, namely proliferation, brain invasion, and necrosis. The model is validated and interrogated to derive fundamental insights in cancer biology and on the clinical and biological effects of AA drugs.
HOSTS: Professors O. Karakashian and S. Wise
Refreshments will be available at 3:15 p.m.
Friday, 18 January, 2013
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Knoxville, TN 37996
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