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Computational/Applied Math Seminar at Ayres Hall Room 123

Wednesday, 26 March, 2014

SPEAKER:  Prof. Vasilios Alexiades, UTK

TITLE: Parameter Identification via sensitivity and optimization

ABSTRACT: We study a model of a biochemical cascade (triggered by photons in retinal photoreceptors, which constitutes the first stage of vision). The cascade (with multi-stage shutoff of activated rhodopsin) is described by 70 reactions involving 16 primary parameters. A sensitivity analysis suggests that 4 of the parameters affect the response the most. We present an optimization approach to find parameters that result in desired peak and timing of response matching experimental data.


Ayres Hall Room 123
1403 Circle Drive
Knoxville, TN 37996

Event Contact

Betty Morgan

Phone: 974-2463

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