SPEAKER: Prof. Vasilios Alexiades, UTK
TITLE: Parameter Identification via sensitivity and optimization
ABSTRACT: We study a model of a biochemical cascade (triggered by photons in retinal photoreceptors, which constitutes the first stage of vision). The cascade (with multi-stage shutoff of activated rhodopsin) is described by 70 reactions involving 16 primary parameters. A sensitivity analysis suggests that 4 of the parameters affect the response the most. We present an optimization approach to find parameters that result in desired peak and timing of response matching experimental data.
Wednesday, 26 March, 2014
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