Edward Terry Sanford, who graduated in 1883, was a U.S. Supreme Court justice from 1923 to 1930.

James Percy Priest attended UT in Knoxville in 1923. He was a member of the U.S. House of Representatives from 1940 to 1956.

Thomas A.R. Nelson graduated in 1828 and served in the U.S. House of Representatives and on the Tennessee Supreme Court. He was counsel to President Andrew Johnson during his impeachment trial in 1868.

John E. McCall (1881) was editor of the Tennessee Republican and served in both the Tennessee and the U.S. House of Representatives.

Ed Jones attended UT Junior College (now UT Martin) and graduated from UT in Knoxville in 1934. He was Tennessee commissioner of agriculture from 1949 to 1952 and served in the U.S. House of Representatives from 1969 to 1989.

Thomas G. Hull (1951) was chief U.S. district judge in Greeneville, Tennessee. He was elected to the U.S. House of Representatives in 1955.

John Chiles Houk attended UT Knoxville from 1872 to 1879. He was a member of the U.S. House of Representatives from 1891 to 1895 and later served in the Tennessee Senate.

John J. Duncan Sr. attended UT from 1939 to 1941. He was mayor of Knoxville and served in the U.S. House of Representatives.

John Hervey Crozier (1829) was president of the Knoxville and Kentucky Railroad and served in the U.S. House of Representatives from 1845 to 1849.

Walter C. Chandler (1909) was a member of the U.S. House of Representatives from 1935 to 1940 and served as mayor of Memphis from 1940 to 1946 and in 1955.